Clinical Effectiveness and Outcomes of Azithromycin versus Doxycycline Containing Regimen in Inpatients with Community Acquired Pneumonia: A Retrospective Cohort Study
نویسندگان
چکیده
Background. Community acquired pneumonia (CAP) is a common serious infection that usually treated with macrolide β-lactam while doxycycline considered an alternative due to limited evidence. Hence, we aimed evaluate azithromycin versus containing regimen in achieving clinical stability for inpatients CAP. Materials and Methods. retrospective cohort of CAP receiving either or combined β-lactam. The primary endpoint was the percentage patients who achieved within 3 days, secondary endpoints were average days required achieve stability. Results. A total 447 included which 379 received 68 regimen. age study population 65.4 ± 21.1, 49% females. Ceftriaxone most prescribed Majority this had length hospital stay 5 less. Total 257 (57.5%), 222 (58.6%) group 35 (51.5%) group; p = 0.275 . While day both groups 3.8 3.2, 3.3 3.9 2.7 regimen; (95% CI −0.98–0.68; id="M2"> 0.727 ) Conclusions. These findings support comparable efficacy macrolides as supported by current guideline recommendations.
منابع مشابه
Doxycycline for community-acquired pneumonia.
Sir—I read with interest the article by Johnson [1] suggesting a more prominent role for doxycycline in empiric therapy for community-acquired pneumonia (CAP). A response by Lederman et al. [2] described an in vitro susceptibility survey that compared tetracycline with doxycy-cline against bacterial pathogens causing CAP. The survey emphasized the relative lack of susceptibility of Streptococcu...
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ژورنال
عنوان ژورنال: Journal of Clinical Pharmacy and Therapeutics
سال: 2023
ISSN: ['1365-2710', '0269-4727']
DOI: https://doi.org/10.1155/2023/8861376